Heritable sperm chromatin epigenetics: a break to remember†
نویسندگان
چکیده
منابع مشابه
Chromatin structure and epigenetics.
In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base pairs of DNA wrapped around an octamer of core histones (made of two molecules of each H2A, H2B, H3, and H4 histones). Each nucleosome is linked to the next by small segments of linker DNA. Most chromatin is further co...
متن کاملIntroduction to theme "Chromatin, epigenetics, and transcription".
Transcriptional regulation in eukaryotes depends on a complex network of interactions between RNA polymerases and a host of transcription factors and coregulators that control their activity during transcription initiation and elongation. Among these are an enormous variety of enzymes and proteins that modulate chromatin structure via changes in DNA methylation, histone modifications, and nucle...
متن کاملChromatin at the crossroads. Meeting on signalling to chromatin epigenetics.
Introduction In June 2006, about 90 scientists came together at the Wellcome Trust Conference Centre in Hinxton (near Cambridge, UK), to attend the first European Science Foundation (ESF)–Wellcome Trust Conference on Signalling to Chromatin Epigenetics. This meeting addressed how cellular processes both signal and respond to chromatin. Chromatin is composed of nucleosomes that each comprise 147...
متن کاملChromatin and Epigenetics
Wrapping DNA around protein beads, to form socalled nucleosomes, is an ingenious invention of nature allowing the condensation of an enormous amount of genomic information into a tiny package. The assembly of DNAwith histone proteins, the chromatin, increases genome stability, but it also hinders the access of enzymes needed to transcribe the encoded information. Bliss or burden, the chromatin ...
متن کاملEtiology and Evaluation of Sperm Chromatin Anomalies
Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomes and infertile men possess substantially amount of sperm with chromatin anomalies than fertile men. Routine semen analysis evaluates parameters such as sperm motility and morphology, but does not examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclear chromatin struc...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2017
ISSN: 0006-3363,1529-7268
DOI: 10.1093/biolre/iox137